Excipients for Oral & TopicalUSP/NFPh. Eur.JP
Poloxamer 188
Non-ionic block copolymer surfactant & protein aggregation protector
Poloxamer 188 is a non-ionic block copolymer composed of PEO and PPO, widely used to solubilize APIs and protect proteins/biologics from aggregation.
infoProduct Description
Poloxamer 188 is a non-ionic block copolymer surfactant composed of polyethylene oxide (PEO) and polypropylene oxide (PPO). It is widely used as a pharmaceutical excipient for its excellent solubilizing, emulsifying, wetting, and stabilizing properties. Poloxamer 188 enhances API solubility and protects proteins and biologics from aggregation.
starsKey Features & Advantages
- task_altExcellent non-ionic surfactant with superior solubilizing properties
- task_altEnhances the solubility of poorly water-soluble APIs
- task_altEffective emulsifier and wetting agent
- task_altImproves formulation stability and prevents phase separation
- task_altProtects proteins and biologics from aggregation and surface adsorption
- task_altSuitable for oral and topical formulations
- task_altEnhances drug bioavailability and uniform API dispersion
- task_altLow toxicity and non-irritating with excellent biocompatibility
- task_altStable over a wide pH and temperature range
- task_altCompatible with a broad range of pharmaceutical excipients and APIs
- task_altEffective at low concentrations
- task_altAvailable in USP/NF, Ph. Eur., and JP compliant pharmaceutical grades
sciencePharmaceutical Applications
verifiedOral & Topical Solubilization
fact_checkKey Specifications
Structure
Triblock Copolymer (PEO-PPO-PEO)
Grade
USP/NF, Ph. Eur., JP Compliant
verifiedQuality Assurance
Global GMP Compliant & Pharmacopeia Grade